Normal fasting triglyceride levels and incident type 2 diabetes in the general population.

ABSTRACT:

Background

Type 2 diabetes is increasing worldwide. Traditionally, only hypertriglyceridemia is considered a risk factor. We investigated whether also normal triglycerides prospectively associate with incident type 2 diabetes in healthy subjects.

Methods

Incident type 2 diabetes was determined in healthy individuals with normal triglyceride levels from a prospective longitudinal cohort study (PREVEND, n = 2085, 11.4-year median follow-up).

Results

Type 2 diabetes incidence was 3.8%. In linear regression analysis baseline insulin, HOMA-IR, total cholesterol, HDL cholesterol, eGFR, systolic blood pressure (all p < 0.001), glucose, age and creatinine (all p < 0.01) independently associated with triglycerides within the normal range, comparable to what would be expected f

SUBMITTER: Szili-Torok T 

PROVIDER: S-EPMC9206357 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature