Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model.

ABSTRACT:

Purpose

Toothache, a common disorder afflicting most people, shows distinct features at different clinical stages. This study aimed to depict metabolic changes in brain and investigate the potential mechanism involved in the aberrant affective behaviors during the natural process of toothache.

Methods

We investigated the spatiotemporal patterns of brain function during the natural course of toothache in a rat model of dental pulp injury (DPI) by using positron emission tomography (PET).

Results

Glucose metabolism peaked on the 3rd day and gradually decreased in several brain regions after DPI, which was in line with the behavioral and histological results. PET imaging showed that visual pathway was involved in the regulation of toothache. Meanwhile, the process of emo

SUBMITTER: Yu F 

PROVIDER: S-EPMC9206688 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature