Dataset Information
Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model.
Ontology highlight
ABSTRACT: Purpose
Toothache, a common disorder afflicting most people, shows distinct features at different clinical stages. This study aimed to depict metabolic changes in brain and investigate the potential mechanism involved in the aberrant affective behaviors during the natural process of toothache.Methods
We investigated the spatiotemporal patterns of brain function during the natural course of toothache in a rat model of dental pulp injury (DPI) by using positron emission tomography (PET).Results
Glucose metabolism peaked on the 3rd day and gradually decreased in several brain regions after DPI, which was in line with the behavioral and histological results. PET imaging showed that visual pathway was involved in the regulation of toothache. Meanwhile, the process of emotional regulation underlying toothache was mediated by N-methyl-D-aspartic receptor subunit 2B (NR2B) in the caudal anterior cingulate cortex (cACC).Conclusion
Our results revealed the spatiotemporal neurofunctional patterns during toothache process and preliminarily elucidated the role of NR2B in cACC in the regulation of toothache-related affective behaviors.
SUBMITTER: Yu F
PROVIDER: S-EPMC9206688 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model.
European journal of nuclear medicine and molecular imaging 20220319 8
<h4>Purpose</h4>Toothache, a common disorder afflicting most people, shows distinct features at different clinical stages. This study aimed to depict metabolic changes in brain and investigate the potential mechanism involved in the aberrant affective behaviors during the natural process of toothache.<h4>Methods</h4>We investigated the spatiotemporal patterns of brain function during the natural course of toothache in a rat model of dental pulp injury (DPI) by using positron emission tomography ...[more]
