Dataset Information

Factors associated with TNF-alpha levels in patients with indirect inguinal hernia: A cross-sectional study

ABSTRACT:

Introduction

Risk factors associated with inguinal hernia include a patent processus vaginalis due to an obliteration failure, defects in the transversalis fascia, increased intra-abdominal pressure, smoking, malnutrition, genetic factors, connective tissue defects and impaired collagen metabolism. Type I collagen predominates in the fascia, which plays a key role in the development of an inguinal hernia. Molecularly, the production of abnormal matrix components or increased inflammatory mediators in collagen such as TNF-α has a very important role in the occurrence of inflammation in inguinal hernias. The study aimed to determine the factors associated with TNF-alpha levels in patients with indirect inguinal hernias.

Methods

We evaluate the effect of TNF-α on the anterior rectus sheath tissue collagen in 46 patients with indirect inguinal hernia using a cross-sectional study design. The ELISA method was used to evaluate the levels of collagen TNF-α. We used ANOVA, Pearson's correlation test, and Spearman's correlation test to determine which results were statistically significant, defined by a p-value < 0.05.

Results

Body mass index (BMI) average results were 25.7 kg/m2. Mean clinical onset was 70.13 months across 46 samples. TNF-α levels and BMI were correlated (p = 0.009). The TNF-α levels in the clinical-grade group (p = 0.044) and the clinical onset group (p = 0.047) varied according to ANOVA.

Conclusion

Clinical onset, BMI, clinical grade of indirect inguinal hernia, and TNF-α levels have a significant relationship. Highlights • Several risk factors are associated with inguinal hernia.• TNF-α inhibits the synthesis of structural components, which lowers extracellular matrix deposition.• TNF-α inhibits type I collagen gene expression by TGF-β, disrupting the structure and strength of the abdominal wall.• Clinical onset, body mass index, and clinical grade of indirect inguinal hernia all significantly correlate with TNF-α levels.• Age and occupational group do not have a significant relationship with TNF-α levels.

SUBMITTER: Warsinggih

PROVIDER: S-EPMC9207110 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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