MRNAsi-related genes can effectively distinguish hepatocellular carcinoma into new molecular subtypes.

ABSTRACT:

Background

Recent studies have shown that the mRNA expression-based stemness index (mRNAsi) can accurately quantify the similarity of cancer cells to stem cells, and mRNAsi-related genes are used as biomarkers for cancer. However, mRNAsi-driven tumor heterogeneity is rarely investigated, especially whether mRNAsi can distinguish hepatocellular carcinoma (HCC) into different molecular subtypes is still largely unknown.

Methods

Using OCLR machine learning algorithm, weighted gene co-expression network analysis, consistent unsupervised clustering, survival analysis and multivariate cox regression etc. to identify biomarkers and molecular subtypes related to tumor stemness in HCC.

Results

We firstly demonstrate that the high mRNAsi is significantly associated with the poo

SUBMITTER: Wang C 

PROVIDER: S-EPMC9207218 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature