Dataset Information

Is living in a household with children associated with SARS-CoV-2 seropositivity in adults? Results from the Swiss national seroprevalence study Corona Immunitas.

ABSTRACT:

Background

We aimed to determine whether living in a household with children is associated with SARS-CoV-2 seropositivity in adults and investigated interacting factors that may influence this association.

Methods

SARS-CoV-2 serology testing was performed in randomly selected individuals from the general population between end of October 2020 and February 2021 in 11 cantons in Switzerland. Data on sociodemographic and household characteristics, employment status, and health-related history was collected using questionnaires. Multivariable logistic regression was used to examine the association of living with children <18 years of age (number, age group) and SARS-CoV-2 seropositivity. Further, we assessed the influence of reported non-household contacts, employment status, and gender.

Results

Of 2393 working age participants (18-64 years), 413 (17.2%) were seropositive. Our results suggest that living with children and SARS-CoV-2 seropositivity are likely to be associated (unadjusted odds ratio (OR) 1.22, 95% confidence interval [0.98-1.52], adjusted OR 1.25 [0.99-1.58]). A pattern of a positive association was also found for subgroups of children aged 0-11 years (OR 1.21 [0.90-1.60]) and 12-17 years (OR 1.14 [0.78-1.64]). Odds of seropositivity were higher with more children (OR 1.14 per additional child [1.02-1.27]). Men had higher risk of SARS-CoV-2 infection when living with children than women (interaction: OR 1.74 [1.10-2.76]).

Conclusions

In adults from the general population living with children seems associated with SARS-CoV-2 seropositivity. However, child-related infection risk is not the same for every subgroup and depends on factors like gender. Further factors determining child-related infection risk need to be identified and causal links investigated.

Trial registration

https://www.isrctn.com/ISRCTN18181860 .

SUBMITTER: Blankenberger J

PROVIDER: S-EPMC9207841 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Is living in a household with children associated with SARS-CoV-2 seropositivity in adults? Results from the Swiss national seroprevalence study Corona Immunitas.

Blankenberger Jacob J Kaufmann Marco M Albanese Emiliano E Amati Rebecca R Anker Daniela D Camerini Anne-Linda AL Chocano-Bedoya Patricia P Cullati Stéphane S Cusini Alexia A Fehr Jan J Harju Erika E Kohler Philipp P Kriemler Susi S Michel Gisela G Rodondi Nicolas N Rodondi Pierre-Yves PY Speierer Alexandre A Tancredi Stefano S Puhan Milo A MA Kahlert Christian R CR

BMC medicine 20220620 1

<h4>Background</h4>We aimed to determine whether living in a household with children is associated with SARS-CoV-2 seropositivity in adults and investigated interacting factors that may influence this association.<h4>Methods</h4>SARS-CoV-2 serology testing was performed in randomly selected individuals from the general population between end of October 2020 and February 2021 in 11 cantons in Switzerland. Data on sociodemographic and household characteristics, employment status, and health-relate ...[more]

PMID: 35725472

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Dataset Information

Is living in a household with children associated with SARS-CoV-2 seropositivity in adults? Results from the Swiss national seroprevalence study Corona Immunitas.

Background

Methods

Results

Conclusions

Trial registration

Publications

Is living in a household with children associated with SARS-CoV-2 seropositivity in adults? Results from the Swiss national seroprevalence study Corona Immunitas.

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