Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction.

ABSTRACT: Homoarginine is an endogenous amino acid whose levels are reduced in patients with renal, cardio- and cerebrovascular disease. Moreover, low homoarginine concentrations independently predict morbidity and mortality in these patients. Besides endogenous synthesis, homoarginine is also a constituent of the human diet. The objective of the present study was to analyze the kinetics of orally supplemented homoarginine in human plasma by means of a pharmacometric approach. We developed a pharmacometric model to evaluate different dosing regimens, especially the regimen of 125 mg once weekly, based on a previous clinical study (n = 20). The model was adapted to account for differences in baseline homoarginine plasma concentrations between healthy and diseased individuals. A novel dosing regimen o

SUBMITTER: Kleist CJ 

PROVIDER: S-EPMC9213336 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature