An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis.
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ABSTRACT:
SUBMITTER: Danoff JS
PROVIDER: S-EPMC9216658 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
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An epigenetic rheostat of experience: DNA methylation of <i>OXTR</i> as a mechanism of early life allostasis.
Danoff Joshua S JS Connelly Jessica J JJ Morris James P JP Perkeybile Allison M AM
Comprehensive psychoneuroendocrinology 20211114
Oxytocin is a neuropeptide hormone which is involved in regulation of social behavior, stress response, muscle contraction, and metabolism. Oxytocin signaling is dependent on its binding to the oxytocin receptor, coded for by the <i>OXTR</i> gene. Many studies have examined the role of epigenetic regulation of <i>OXTR</i> in neurological and behavioral outcomes in both humans and animal models. Here, we review these studies, critically analyze their findings in the context of oxytocin's role as ...[more]
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