Dataset Information

Subjective age and inflammation risk in midlife adults: Findings from the Midlife in the United States (MIDUS) studies.

ABSTRACT: Recent studies have suggested that subjective age-a subjective evaluation of one's own age-is a promising construct in gerontology that may contribute our understanding of risk for immune dysfunction. Nevertheless, studies documenting the association between subjective age and inflammatory biomarkers remain limited and provide mixed findings. In the present study, we revisited the relation between subjective age and systemic inflammation by utilizing a range of well-established inflammatory biomarkers (C-reactive protein, interleukin-6, fibrinogen, E-selectin, and intercellular adhesion molecule 1) through the collection of fasting blood samples before breakfast. In a large-scale dataset of midlife adults (N = 1800), we found some evidence that an older subjective age is associated with elevated inflammation when indexed by C-reactive protein and fibrinogen, as well as a composite inflammation score. However, these relations were not significant when health variables were controlled for, suggesting that the association between subjective age and systemic inflammation is fully accounted for by better health profiles among those with a younger subjective age. Additionally, the subjective age-inflammation association was influenced by slight variations in the analytic method, highlighting the importance of sensitivity analyses in this area.

SUBMITTER: Hartanto A

PROVIDER: S-EPMC9216680 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Subjective age and inflammation risk in midlife adults: Findings from the Midlife in the United States (MIDUS) studies.

Hartanto Andree A Majeed Nadyanna M NM Ng Wee Qin WQ Chai Colin Kai Ning CKN Lua Verity Yu Qing VYQ

Comprehensive psychoneuroendocrinology 20210724

Recent studies have suggested that subjective age-a subjective evaluation of one's own age-is a promising construct in gerontology that may contribute our understanding of risk for immune dysfunction. Nevertheless, studies documenting the association between subjective age and inflammatory biomarkers remain limited and provide mixed findings. In the present study, we revisited the relation between subjective age and systemic inflammation by utilizing a range of well-established inflammatory biom ...[more]

PMID: 35757054

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Project description:BackgroundThere is a lack of empirical effort that systematically investigates the clustering of comorbidity among known risk factors (obesity, hypertension, diabetes, hypercholesterolemia, and elevated inflammation) of chronic kidney disease (CKD) and how different types of comorbidity may link differently to kidney function among healthy adult samples. This study modeled the clustering of comorbidity among risk factors, examined the association between the clustering of risk factors and kidney function, and tested whether the clustering of risk factors was associated with childhood SES.MethodsThe data were from 2118 participants (ages 25-84) in the Midlife in the United States (MIDUS) Study. Risk factors included obesity, elevated blood pressure (BP), high total cholesterol levels, poor glucose control, and increased inflammatory activity. Glomerular filtration rate (eGFR) was estimated from serum creatinine, calculated with the CKD-EPI formula. The clustering of comorbidity among risk factors and its association with kidney function and childhood SES were examined using latent class analysis (LCA).ResultsA five-class model was optimal: (1) Low Risk (class size = 36.40%; low probability of all risk factors), (2) Obese (16.42%; high probability of large BMI and abdominally obese), (3) Obese and Elevated BP (13.37%; high probability of being obese and having elevated BP), (4) Non-Obese but Elevated BP (14.95%; high probability of having elevated BP, hypercholesterolemia, and elevated inflammation), and (5) High Risk (18.86%; high probability for all risk factors). Obesity was associated with kidney hyperfiltration, while comorbidity between obesity and hypertension was linked to compromised kidney filtration. As expected, the High Risk class showed the highest probability of having eGFR < 60 ml/min/1.73 m2 (P = .12; 95%CI = .09-.17). Finally, higher childhood SES was associated with reduced probability of being in the High Risk rather than Low Risk class (β = - 0.20, SE = 0.07, OR [95%CI] = 0.82 [0.71-0.95]).ConclusionThese results highlight the importance of considering the impact of childhood SES on risk factors known to be associated with CKD.

Dataset Information

Subjective age and inflammation risk in midlife adults: Findings from the Midlife in the United States (MIDUS) studies.

Publications

Subjective age and inflammation risk in midlife adults: Findings from the Midlife in the United States (MIDUS) studies.

Similar Datasets

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