Unknown

Dataset Information

0

Bacillus Calmette-Guerin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice.


ABSTRACT: SARS-CoV-2 has been confirmed in over 450 million confirmed cases since 2019. Although several vaccines have been certified by the WHO and people are being vaccinated on a global scale, it has been reported that multiple SARS-CoV-2 variants can escape neutralization by antibodies, resulting in vaccine breakthrough infections. Bacillus Calmette-Guérin (BCG) is known to induce heterologous protection based on trained immune responses. Here, we investigated whether BCG-induced trained immunity protected against SARS-CoV-2 in the K18-hACE2 mouse model. Our data demonstrate that i.v. BCG (BCG-i.v.) vaccination induces robust trained innate immune responses and provides protection against WT SARS-CoV-2, as well as the B.1.617.1 and B.1.617.2 variants. Further studies suggest that myeloid cell differentiation and activation of the glycolysis pathway are associated with BCG-induced training immunity in K18-hACE2 mice. Overall, our study provides the experimental evidence that establishes a causal relationship between BCG-i.v. vaccination and protection against SARS-CoV-2 challenge.

SUBMITTER: Zhang BZ 

PROVIDER: S-EPMC9220951 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications


SARS-CoV-2 has been confirmed in over 450 million confirmed cases since 2019. Although several vaccines have been certified by the WHO and people are being vaccinated on a global scale, it has been reported that multiple SARS-CoV-2 variants can escape neutralization by antibodies, resulting in vaccine breakthrough infections. Bacillus Calmette-Guérin (BCG) is known to induce heterologous protection based on trained immune responses. Here, we investigated whether BCG-induced trained immunity prot  ...[more]

Similar Datasets

| S-EPMC7564904 | biostudies-literature
| S-EPMC9327679 | biostudies-literature
| S-EPMC8921182 | biostudies-literature
| S-EPMC10303402 | biostudies-literature
| S-EPMC10300285 | biostudies-literature
| S-EPMC5936970 | biostudies-literature
| S-EPMC10974247 | biostudies-literature
| S-EPMC10530434 | biostudies-literature
| S-EPMC9032525 | biostudies-literature
| S-EPMC7921379 | biostudies-literature