No optical coherence tomography changes in premanifest Huntington's disease mutation carriers far from disease onset.

ABSTRACT:

Background

Spectral-domain optical coherence tomography (OCT) may detect retinal changes as a biomarker in neurodegenerative diseases like manifest Huntington's disease (HD). We investigate macular retinal layer thicknesses in a premanifest HD (pre-HD) cohort and healthy controls (HC).

Methods

Pre-HD mutation carriers underwent standardized ratings and a preset macular OCT scan. Thickness values were determined for each sector of all macular retinal layers, the mean of all sectors and the mean of the inner ring (IR, 3 mm) after segmentation (Heyex segmentation batch). HC were retrospectively included from an existing database. The IR thickness of the ganglion cell layer (GCL), retinal nerve fiber layer (RNFL), GCL + inner plexiform layer (GCIPL), and total retina were includ

SUBMITTER: Schmid RD 

PROVIDER: S-EPMC9226796 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature