Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic Options.

ABSTRACT: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. SARS-CoV-2 is characterized by an important capacity to circumvent the innate immune response. The early interferon (IFN) response is necessary to establish a robust antiviral state. However, this response is weak and delayed in COVID-19 patients, along with massive pro-inflammatory cytokine production. This dysregulated innate immune response contributes to pathogenicity and in some individuals leads to a critical state. Characterizing the interplay between viral factors and host innate immunity is crucial to better understand how to manage the disease. Moreover, the constant emergence of new SARS-CoV-2 variants challenges the efficacy of existing vaccines. Thus, to control this

SUBMITTER: Znaidia M 

PROVIDER: S-EPMC9231409 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature