Ectopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia.

ABSTRACT:

Background

T cell acute lymphoblastic leukemia (T-ALL) defines a group of hematological malignancies with heterogeneous aggressiveness and highly variable outcome, making therapeutic decisions a challenging task. We tried to discover new predictive model for T-ALL before treatment by using a specific pipeline designed to discover aberrantly active gene.

Results

The expression of 18 genes was significantly associated with shorter survival, including ACTRT2, GOT1L1, SPATA45, TOPAZ1 and ZPBP (5-GEC), which were used as a basis to design a prognostic classifier for T-ALL patients. The molecular characterization of the 5-GEC positive T-ALL unveiled specific characteristics inherent to the most aggressive T leukemic cells, including a drastic shut-down of genes located on the mito

SUBMITTER: Peng LJ 

PROVIDER: S-EPMC9233359 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature