Role of renin-angiotensin system antagonists on long-term mortality post-percutaneous coronary intervention in reduced and preserved ejection fraction.

ABSTRACT:

Aims

The use of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II-receptor blockers (ARBs) post-myocardial infarction (MI) is supported by evidence based on trials performed in the thrombolysis era. This was prior to primary percutaneous coronary intervention (PCI) being routine practice, and with little direct evidence for the use of these medications in patients with preserved left ventricular (LV) function. This study sought to determine whether there is an association between ACEi/ARB use after PCI for acute coronary syndrome (ACS) and long-term all-cause mortality, with a particular focus on patients with preserved LV function.

Methods

This multicentre, observational study evaluated prospectively collected data of 21,388 patients (> 18 years old) that un

SUBMITTER: Prosser HC 

PROVIDER: S-EPMC9242972 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature