Dataset Information

Plasma Metabolomics Profiles are Associated with the Amount and Source of Protein Intake: A Metabolomics Approach within the PREDIMED Study.

ABSTRACT:

Scope

The plasma metabolomics profiles of protein intake have been rarely investigated. The aim is to identify the distinct plasma metabolomics profiles associated with overall intakes of protein as well as with intakes from animal and plant protein sources.

Methods and results

A cross-sectional analysis using data from 1833 participants at high risk of cardiovascular disease is conducted. Associations between 385 identified metabolites and the intake of total, animal protein (AP), and plant protein (PP), and plant-to-animal ratio (PR) are assessed using elastic net continuous regression analyses. A double 10-cross-validation (CV) procedure is used and Pearson correlations coefficients between multi-metabolite weighted models and reported protein intake in each pair of training-validation datasets are calculated. A wide set of metabolites is consistently associated with each protein source evaluated. These metabolites mainly consisted of amino acids and their derivatives, acylcarnitines, different organic acids, and lipid species. Few metabolites overlapped among protein sources (i.e., C14:0 SM, C20:4 carnitine, GABA, and allantoin) but none of them toward the same direction. Regarding AP and PP approaches, C20:4 carnitine and dimethylglycine are positively associated with PP but negatively associated with AP. However, allantoin, C14:0 SM, C38:7 PE plasmalogen, GABA, metronidazole, and trigonelline (N-methylnicotinate) behave contrarily. Ten-CV Pearson correlation coefficients between self-reported protein intake and plasma metabolomics profiles range from 0.21 for PR to 0.32 for total protein.

Conclusions

Different sets of metabolites are associated with total, animal, and plant protein intake. Further studies are needed to assess the contribution of these metabolites in protein biomarkers' discovery and prediction of cardiometabolic alterations.

SUBMITTER: Hernandez-Alonso P

PROVIDER: S-EPMC9245364 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Publications

Plasma Metabolomics Profiles are Associated with the Amount and Source of Protein Intake: A Metabolomics Approach within the PREDIMED Study.

Hernández-Alonso Pablo P Becerra-Tomás Nerea N Papandreou Christopher C Bulló Mònica M Guasch-Ferré Marta M Toledo Estefanía E Ruiz-Canela Miguel M Clish Clary B CB Corella Dolores D Dennis Courtney C Deik Amy A Wang Dong D DD Razquin Cristina C Drouin-Chartier Jean-Philippe JP Estruch Ramon R Ros Emilio E Fitó Montserrat M Arós Fernando F Fiol Miquel M Serra-Majem Lluís L Liang Liming L Martínez-González Miguel A MA Hu Frank B FB Salas-Salvadó Jordi J

Molecular nutrition & food research 20200525 12

<h4>Scope</h4>The plasma metabolomics profiles of protein intake have been rarely investigated. The aim is to identify the distinct plasma metabolomics profiles associated with overall intakes of protein as well as with intakes from animal and plant protein sources.<h4>Methods and results</h4>A cross-sectional analysis using data from 1833 participants at high risk of cardiovascular disease is conducted. Associations between 385 identified metabolites and the intake of total, animal protein (AP) ...[more]

PMID: 32378786

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Dataset Information

Plasma Metabolomics Profiles are Associated with the Amount and Source of Protein Intake: A Metabolomics Approach within the PREDIMED Study.

Scope

Methods and results

Conclusions

Publications

Plasma Metabolomics Profiles are Associated with the Amount and Source of Protein Intake: A Metabolomics Approach within the PREDIMED Study.

Similar Datasets

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