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A model of actin-driven endocytosis explains differences of endocytic motility in budding and fission yeast.

ABSTRACT: A comparative study (Sun et al., 2019) showed that the abundance of proteins at sites of endocytosis in fission and budding yeast is more similar in the two species than previously thought, yet membrane invaginations in fission yeast elongate twofold faster and are nearly twice as long as in budding yeast. Here we use a three-dimensional model of a motile endocytic invagination (Nickaeen et al., 2019) to investigate factors affecting elongation of the invaginations. We found that differences in turgor pressure in the two yeast species can largely explain the paradoxical differences observed experimentally in endocytic motility.

SUBMITTER: Nickaeen M

PROVIDER: S-EPMC9250386 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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A model of actin-driven endocytosis explains differences of endocytic motility in budding and fission yeast.

Nickaeen Masoud M Berro Julien J Pollard Thomas D TD Slepchenko Boris M BM

Molecular biology of the cell 20211215 3

A comparative study (Sun <i>et al.</i>, 2019) showed that the abundance of proteins at sites of endocytosis in fission and budding yeast is more similar in the two species than previously thought, yet membrane invaginations in fission yeast elongate twofold faster and are nearly twice as long as in budding yeast. Here we use a three-dimensional model of a motile endocytic invagination (Nickaeen <i>et al.</i>, 2019) to investigate factors affecting elongation of the invaginations. We found that d ...[more]

PMID: 34910589

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