CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma.

ABSTRACT:

Purpose

The immunosuppressive tumor microenvironment present in the majority of diffuse glioma limits therapeutic response to immunotherapy. As the determinants of the glioma-associated immune response are relatively poorly understood, the study of glioma with more robust tumor-associated immune responses may be particularly useful to identify novel immunomodulatory factors that can promote T-cell effector function in glioma.

Experimental design

We used multiplex immune-profiling, proteomic profiling, and gene expression analysis to define the tumor-associated immune response in two molecular subtypes of glioma and identify factors that may modulate this response. We then used patient-derived glioma cultures and an immunocompetent murine model for malignant glioma to analyze

SUBMITTER: Kumar A 

PROVIDER: S-EPMC9250623 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature