Variants in PRKCE and KLC1, Potential Regulators of Type I Psoriasis.

ABSTRACT:

Purpose

Psoriasis is a multifactorial disease with a complex genetic predisposition. The pathophysiology of psoriasis is associated with genetic variants. To better characterize gene variants in psoriasis and identify the relationship between clinical characteristics and variant genes in its pathogenesis.

Patients and methods

DNA was extracted and purified from eight pairs of monozygotic twins with psoriasis discordance and 282 type I psoriasis patients. Thirteen variable genes were amplified and sequenced using the Sanger method after whole genome sequencing.

Results

Thirteen genes were found to be variable in eight pairs of monozygotic twins with psoriasis discordance. Among the 13 genes, the variant frequencies of protein kinase C epsilon (PRKCE) (c.240T>C, 35.9% v

SUBMITTER: Xing J 

PROVIDER: S-EPMC9255717 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature