Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines.

ABSTRACT: One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures. This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines, tested regarding their morphology and thermal, crystallographic, and spectroscopic profiles. Generally, despite the strong drug-polymer interactions observed, the chemical stability of the model drugs was preserved under such conditions. In fact, in the metoprolol and Soluplus® composition, the drug's solubilization in the polymer produced a delay in the drug decomposition, suggesting a protective effect of the matrix. Paracetamol and polyvinyl alcohol mixture, in turn, showed unmistakable signs of th

SUBMITTER: Silva IA 

PROVIDER: S-EPMC9257448 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature