Abnormal urinary loss of vitamin C in diabetes: prevalence and clinical characteristics of a vitamin C renal leak.

ABSTRACT:

Background

Diabetes is associated with low plasma vitamin C concentrations.

Objectives

We investigated the contribution of dysregulated vitamin C renal physiology, its prevalence, and associated clinical characteristics.

Methods

An essential prerequisite was determination of normal vitamin C renal threshold, the plasma concentration at which vitamin C first appears in urine. Using data from 17 healthy participants who underwent vitamin C depletion-repletion studies with a vitamin C dose range of 15-1250 mg daily, renal threshold was estimated using physiology-based pharmacokinetics modeling. Applying renal threshold 95% CIs, we estimated the minimal elimination threshold, the plasma concentration below which no vitamin C was expected in urine of healthy people. Renal

SUBMITTER: Ebenuwa I 

PROVIDER: S-EPMC9257470 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature