Molecular Signature of ¹⁸F-FDG PET Biomarkers in Newly Diagnosed Multiple Myeloma Patients: A Genome-Wide Transcriptome Analysis from the CASSIOPET Study.

ABSTRACT: The International Myeloma Working Group recently fully incorporated ¹⁸F-FDG PET into multiple myeloma (MM) diagnosis and response evaluation. Moreover, a few studies demonstrated the prognostic value of several biomarkers extracted from this imaging at baseline. Before these ¹⁸F-FDG PET biomarkers could be fully endorsed as risk classifiers by the hematologist community, further characterization of underlying molecular aspects was necessary. Methods: Reported prognostic biomarkers (¹⁸F-FDG avidity, SUV_max, number of focal lesions, presence of paramedullary disease [PMD] or extramedullary disease) were extracted from ¹⁸F-FDG PET imaging at baseline in a group of 139 patients from CASSIOPET, a companion study of the CASSIOPEIA coh

SUBMITTER: Alberge JB 

PROVIDER: S-EPMC9258580 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature