Moderate to Severe Soft Tissue Diabetic Foot Infections: A Randomized, Controlled, Pilot Trial of Post-debridement Antibiotic Treatment for 10 versus 20 days.

ABSTRACT:

Background

The optimal duration of antibiotic therapy for soft-tissue infections of the diabetic foot remains unknown.

Objective

We determine if antibiotic therapy after debridement for a short (10 days), compared with a long (20 days), duration for soft-tissue infections of the diabetic foot results in similar rates of clinical remission and adverse events (AE).

Summary of background data

The optimal duration of systemic antibiotic therapy, after successful debridement, for soft tissue infections of diabetic patients is unknown. Because of the high recurrence risk, overuse is commonplace.

Methods

This was a randomized, controlled, non-inferiority pilot trial of cases of diabetic foot infection (excluding osteomyelitis) with the primary outcome of "clinical rem

SUBMITTER: Pham TT 

PROVIDER: S-EPMC9259031 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature