Late-life physical activity relates to brain tissue synaptic integrity markers in older adults.

ABSTRACT:

Introduction

Physical activity (PA) is widely recommended for age-related brain health, yet its neurobiology is not well understood. Animal models indicate PA is synaptogenic. We examined the relationship between PA and synaptic integrity markers in older adults.

Methods

Four hundred four decedents from the Rush Memory and Aging Project completed annual actigraphy monitoring (Mean visits = 3.5±2.4) and post mortem evaluation. Brain tissue was analyzed for presynaptic proteins (synaptophysin, synaptotagmin-1, vesicle-associated membrane proteins, syntaxin, complexin-I, and complexin-II), and neuropathology. Models examined relationships between late-life PA (averaged across visits), and timing-specific PA (time to autopsy) with synaptic proteins.

Results

Greater late-l

SUBMITTER: Casaletto K 

PROVIDER: S-EPMC9259753 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature