Dataset Information

Evaluation of the prognostic value of lymphadenectomy for low-grade serous ovarian cancer: A case-control multicenter retrospective study.

ABSTRACT:

Background

The prognostic value of lymphadenectomy in low-grade serous ovarian cancer (LGSOC) remains uncertain.

Materials and methods

A retrospective analysis of 155 patients with LGSOC who underwent surgery over a ten-year period (2011-2020) was performed. The propensity score matching (PSM) algorithm was performed between the lymphadenectomy and no lymphadenectomy groups, and Kaplan-Meier analyses were conducted to evaluate clinical prognosis. Finally, univariate and multivariate Cox proportional hazards regression analyses were performed to analyze high-risk factors associated with clinical prognosis.

Results

In the pre-PSM cohort, 110 (71.0%) patients underwent lymphadenectomy. Of these, 54 (34.8%) experienced recurrence, and 27 (17.4%) died. There were statistical differences in disease-free survival (DFS) (P = 0.018) and overall survival (OS) (P = 0.016) in the post-PSM cohort. In the subgroup analysis, there were no statistically significant differences in DFS (P = 0.449) or OS (P = 0.167) in the FIGO I/II cohort. However, in the FIGO III/IV cohort, DFS (P = 0.011) and OS (P = 0.046) were statistically different between the two groups. Age > 50 years, FIGO stage III/IV, and suboptimal cytoreductive surgery were risk factors associated with prognosis. In the lymphadenectomy group, the histological status of pelvic lymph nodes had no significant effect on DFS (P = 0.205) or OS (P = 0.114).

Conclusion

Lymphadenectomy was associated with DFS and OS, particularly in patients with advanced LGSOC patients. Age > 50 years, advanced FIGO stage III/IV, and suboptimal cytoreductive surgery were high-risk factors associated with clinical prognosis in patients with LGSOC.

SUBMITTER: Chen Z

PROVIDER: S-EPMC9263964 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Evaluation of the prognostic value of lymphadenectomy for low-grade serous ovarian cancer: A case-control multicenter retrospective study.

Chen Zhongshao Z Chu Ran R Shen Yuanming Y Yao Qin Q Chen Jingying J Qin Tianyu T Li Li L Chen Gang G Gao Qinglei Q Sun Chaoyang C Song Li L Li Junting J Liu Penglin P Pan Xiyu X Li Jingnan J Zhu Xiaoying X Zhang Li L Qiao Xu X Ma Ding D Kong Beihua B Song Kun K

Translational oncology 20220704

<h4>Background</h4>The prognostic value of lymphadenectomy in low-grade serous ovarian cancer (LGSOC) remains uncertain.<h4>Materials and methods</h4>A retrospective analysis of 155 patients with LGSOC who underwent surgery over a ten-year period (2011-2020) was performed. The propensity score matching (PSM) algorithm was performed between the lymphadenectomy and no lymphadenectomy groups, and Kaplan-Meier analyses were conducted to evaluate clinical prognosis. Finally, univariate and multivaria ...[more]

PMID: 35797933

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Dataset Information

Evaluation of the prognostic value of lymphadenectomy for low-grade serous ovarian cancer: A case-control multicenter retrospective study.

Background

Materials and methods

Results

Conclusion

Publications

Evaluation of the prognostic value of lymphadenectomy for low-grade serous ovarian cancer: A case-control multicenter retrospective study.

Similar Datasets

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