Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index.

ABSTRACT:

Background

Branched-chain amino acids (BCAAs: isoleucine, leucine, and valine) and aromatic amino acids (AAAs: phenylalanine and tyrosine) are hypothesized to influence early-life obesity risk.

Objective

To assess HM free amino acid (AA) concentrations and infant intakes of HM AAs from women with obesity (OB) compared to those with normal weight (NW) and determine the relationships between HM AA consumption and infant growth.

Methods

HM samples were collected at 0.5 (n = 151), 2 (n = 129), and 6 (n = 93) months postpartum from mothers with NW (body mass index [BMI] = 18.5-24.9 kg/m² ) and OB (BMI > 30 kg/m² ). HM AAs were quantified via mass spectrometry. Infant HM intake, anthropometrics and body composition were assessed. Linear mixed-effects m

SUBMITTER: Saben JL 

PROVIDER: S-EPMC9269030 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature