Dataset Information
An Application of ITO Analysis in Secondary Kinship Identification.
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ABSTRACT: Objective
As the methods of the paternity and kinship testing have been developed, the second-degree and more distant relationships remain challenging in forensic science. Currently, the ITO method is the mainstream method to clarify the kinship between two individuals.Methods
In this study, the ITO algorithm was used to calculate the uncle-nephew index based on 55 autosomal short tandem repeats (STRs) loci that were universally used for forensic identification. 19 STRs loci in Y chromosome were used for verification of the kinship.Results
The cumulative uncle-nephew index between A and B was calculated to 0.993 by the analysis of the genotyping results of 21 STRs. When genotyping results of the other 34 STRs were added to the calculation algorithm, the cumulative uncle-nephew index between A and B was promoted to 227.928. Meanwhile, genotyping results of 17 Y-STRs loci showed that A and B shared the same Y-STRs haplotype that was in accord with the paternal inheritance law.Conclusion
The biological uncle-nephew relationship between A and B are identified by applying the statistical principles and genetic technologies.
SUBMITTER: Zhou P
PROVIDER: S-EPMC9270131 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
An Application of ITO Analysis in Secondary Kinship Identification.
Computational and mathematical methods in medicine 20220701
<h4>Objective</h4>As the methods of the paternity and kinship testing have been developed, the second-degree and more distant relationships remain challenging in forensic science. Currently, the ITO method is the mainstream method to clarify the kinship between two individuals.<h4>Methods</h4>In this study, the ITO algorithm was used to calculate the uncle-nephew index based on 55 autosomal short tandem repeats (STRs) loci that were universally used for forensic identification. 19 STRs loci in Y ...[more]