Does testosterone mediate the relationship between vitamin D and prostate cancer progression? A systematic review and meta-analysis.

ABSTRACT:

Purpose

Observational studies and randomized controlled trials (RCTs) have shown an association between vitamin D levels and prostate cancer progression. However, evidence of direct causality is sparse and studies have not examined biological mechanisms, which can provide information on plausibility and strengthen the evidence for causality.

Methods

We used the World Cancer Research Fund International/University of Bristol two-stage framework for mechanistic systematic reviews. In stage one, both text mining of published literature and expert opinion identified testosterone as a plausible biological mechanism. In stage two, we performed a systematic review and meta-analysis to assess the evidence from both human and animal studies examining the effect of vitamin D on testost

SUBMITTER: Robles LA 

PROVIDER: S-EPMC9270305 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature