Dataset Information

Fulminant myocarditis after the first dose of mRNA-1273 vaccination in a patient with previous COVID-19: a case report.

ABSTRACT:

Background

COVID-19 vaccines have shown success in protecting people worldwide, although serious adverse effects have been reported in very rare cases.

Case summary

A 32-year-old male with a prior medical history of mild COVID-19 infection developed fulminant myocarditis five days after mRNA-1273 vaccination (first dose), which was confirmed using endomyocardial biopsy. He acutely developed respiratory failure and cardiogenic shock with ventricular tachycardia, but recovered completely with short-term high-dose steroid therapy and mechanical cardiac support, which is the recommended treatment for fulminant lymphocytic myocarditis.

Discussion

COVID-19 vaccine-induced myocarditis varies from mild to severe. In the present case, the patient was treated as for fulminant lymphocytic myocarditis and recovered relatively quickly. The mechanism of COVID-19 vaccine-associated myocarditis needs to be urgently investigated.

SUBMITTER: Horiuchi K

PROVIDER: S-EPMC9278249 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Fulminant myocarditis after the first dose of mRNA-1273 vaccination in a patient with previous COVID-19: a case report.

Horiuchi Kohei K Kosugi Shumpei S Abe Haruhiko H Ueda Yasunori Y

European heart journal. Case reports 20220708 7

<h4>Background</h4>COVID-19 vaccines have shown success in protecting people worldwide, although serious adverse effects have been reported in very rare cases.<h4>Case summary</h4>A 32-year-old male with a prior medical history of mild COVID-19 infection developed fulminant myocarditis five days after mRNA-1273 vaccination (first dose), which was confirmed using endomyocardial biopsy. He acutely developed respiratory failure and cardiogenic shock with ventricular tachycardia, but recovered compl ...[more]

PMID: 35860438

Similar Datasets

Project description:BackgroundEvidence indicates that mRNA COVID-19 vaccination is associated with risk of myocarditis and possibly pericarditis, especially in young males. It is not clear if risk differs between mRNA-1273 versus BNT162b2. We assessed if risk differs using comprehensive health records on a diverse population.MethodsMembers 18-39 years of age at eight integrated healthcare-delivery systems were monitored using data updated weekly and supplemented with medical record review of myocarditis and pericarditis cases. Incidence of myocarditis and pericarditis events that occurred among vaccine recipients 0 to 7 days after either dose 1 or 2 of a messenger RNA (mRNA) vaccine was compared with that of vaccinated concurrent comparators who, on the same calendar day, had received their most recent dose 22 to 42 days earlier. Rate ratios (RRs) were estimated by conditional Poisson regression, adjusted for age, sex, race and ethnicity, health plan, and calendar day. Head-to-head comparison directly assessed risk following mRNA-1273 versus BNT162b2 during 0-7 days post-vaccination.ResultsFrom December 14, 2020 - January 15, 2022 there were 41 cases after 2,891,498 doses of BNT162b2 and 38 cases after 1,803,267 doses of mRNA-1273. Cases had similar demographic and clinical characteristics. Most were hospitalized for ≤1 day; none required intensive care. During days 0-7 after dose 2 of BNT162b2, the incidence was 14.3 (CI: 6.5-34.9) times higher than the comparison interval, amounting to 22.4 excess cases per million doses; after mRNA-1273 the incidence was 18.8 (CI: 6.7-64.9) times higher than the comparison interval, amounting to 31.2 excess cases per million doses. In head-to-head comparisons 0-7 days after either dose, risk was moderately higher after mRNA-1273 than after BNT162b2 (RR: 1.61, CI 1.02-2.54).ConclusionsBoth vaccines were associated with increased risk of myocarditis and pericarditis in 18-39-year-olds. Risk estimates were modestly higher after mRNA-1273 than after BNT162b2.

Dataset Information

Fulminant myocarditis after the first dose of mRNA-1273 vaccination in a patient with previous COVID-19: a case report.

Background

Case summary

Discussion

Publications

Fulminant myocarditis after the first dose of mRNA-1273 vaccination in a patient with previous COVID-19: a case report.

Similar Datasets

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