Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp²)-H Functionalization.

ABSTRACT: The palladium-catalyzed C(sp²)-H functionalization of bromoaryl aldonitrones leading to benzocyclobutenone-derived ketonitrones is described. This method allows for the preparation of a wide range of strained, four-membered ketonitrones with broad functional group tolerance. Downstream transformations of the formed products were readily demonstrated, illustrating the synthetic utility of the obtained benzocyclobutenone-derived nitrones for the construction of polycyclic nitrogen-containing scaffolds.

SUBMITTER: Brzeskiewicz J 

PROVIDER: S-EPMC9278523 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature