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Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp²)-H Functionalization.

ABSTRACT: The palladium-catalyzed C(sp²)-H functionalization of bromoaryl aldonitrones leading to benzocyclobutenone-derived ketonitrones is described. This method allows for the preparation of a wide range of strained, four-membered ketonitrones with broad functional group tolerance. Downstream transformations of the formed products were readily demonstrated, illustrating the synthetic utility of the obtained benzocyclobutenone-derived nitrones for the construction of polycyclic nitrogen-containing scaffolds.

SUBMITTER: Brzeskiewicz J

PROVIDER: S-EPMC9278523 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp2)-H Functionalization.

Brześkiewicz Jakub J Loska Rafał R

Organic letters 20220525 22

The palladium-catalyzed C(sp2)-H functionalization of bromoaryl aldonitrones leading to benzocyclobutenone-derived ketonitrones is described. This method allows for the preparation of a wide range of strained, four-membered ketonitrones with broad functional group tolerance. Downstream transformations of the formed products were readily demonstrated, illustrating the synthetic utility of the obtained benzocyclobutenone-derived nitrones for the construction of polycyclic nitrogen-conta ...[more]

PMID: 35613705

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