Ontology highlight
ABSTRACT:
SUBMITTER: Nunes C
PROVIDER: S-EPMC9278860 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Nunes Carolina C Depestel Lisa L Mus Liselot L Keller Kaylee M KM Delhaye Louis L Louwagie Amber A Rishfi Muhammad M Whale Alex A Kara Neesha N Andrews Simon R SR Dela Cruz Filemon F You Daoqi D Siddiquee Armaan A Cologna Camila Takeno CT De Craemer Sam S Dolman Emmy E Bartenhagen Christoph C De Vloed Fanny F Sanders Ellen E Eggermont Aline A Bekaert Sarah-Lee SL Van Loocke Wouter W Bek Jan Willem JW Dewyn Givani G Loontiens Siebe S Van Isterdael Gert G Decaesteker Bieke B Tilleman Laurentijn L Van Nieuwerburgh Filip F Vermeirssen Vanessa V Van Neste Christophe C Ghesquiere Bart B Goossens Steven S Eyckerman Sven S De Preter Katleen K Fischer Matthias M Houseley Jon J Molenaar Jan J De Wilde Bram B Roberts Stephen S SS Durinck Kaat K Speleman Frank F
Science advances 20220713 28
High-risk neuroblastoma, a pediatric tumor originating from the sympathetic nervous system, has a low mutation load but highly recurrent somatic DNA copy number variants. Previously, segmental gains and/or amplifications allowed identification of drivers for neuroblastoma development. Using this approach, combined with gene dosage impact on expression and survival, we identified ribonucleotide reductase subunit M2 (RRM2) as a candidate dependency factor further supported by growth inhibition upo ...[more]