Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain.

ABSTRACT:

Background

Depression is a recurrent and devastating mental disease that is highly prevalent worldwide. Prolonged exposure to stressful events or a stressful environment is detrimental to mental health. In recent years, an inflammatory hypothesis has been implicated in the pathogenesis of stress-induced depression. However, less attention has been given to the initial phases, when a series of stress reactions and immune responses are initiated. Peripheral CD4⁺ T cells have been reported as the major contributors to the occurrence of mental disorders. Chronic stress exposure-evoked release of cytokines can promote the differentiation of peripheral CD4⁺ cells into various phenotypes. Among them, Th17 cells have attracted much attention due to their high pathogen

SUBMITTER: Peng Z 

PROVIDER: S-EPMC9281140 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature