Cross-species incompatibility between a DNA satellite and the Drosophila Spartan homolog poisons germline genome integrity.

ABSTRACT: Satellite DNA spans megabases of eukaryotic sequence and evolves rapidly.^1-6 Paradoxically, satellite-rich genomic regions mediate strictly conserved, essential processes such as chromosome segregation and nuclear structure.^7-10 A leading resolution to this paradox posits that satellite DNA and satellite-associated chromosomal proteins coevolve to preserve these essential functions.¹¹ We experimentally test this model of intragenomic coevolution by conducting the first evolution-guided manipulation of both chromosomal protein and DNA satellite. The 359bp satellite spans an 11 Mb array in Drosophila melanogaster that is absent from its sister species, Drosophila simulans.^12-14 This species-specific DNA satellite colocalizes with the adaptively evo

SUBMITTER: Brand CL 

PROVIDER: S-EPMC9283324 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature