Effect of recombinant human growth hormone on liver fat content in young adults with nonalcoholic fatty liver disease.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in young adults with obesity. Obesity is associated with relative growth hormone (GH) deficiency, and data from animal studies and from humans with pituitary GH deficiency suggest a role for GH deficiency in the pathogenesis of NAFLD. The effects of GH on NAFLD in those with obesity are unknown, however, prompting this pilot study to assess effects of GH administration on measures of NAFLD in young adults.

Methods

Twenty-four men and women aged 18-29 years with BMI ≥ 30 kg/m² , hepatic fat fraction (HFF) ≥ 5% on proton magnetic resonance spectroscopy (¹ H-MRS) and insulin-like growth factor 1 (IGF-1) z-score ≤ 0 were randomized to treatment with recombinant human GH (rhGH) versus no

SUBMITTER: Pan CS 

PROVIDER: S-EPMC9284460 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature