Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.

ABSTRACT:

Background

Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of atherosclerotic plaques containing immune cells in various states of activation and differentiation. Understanding how these immune cells contribute to disease progression may lead to the development of novel therapeutic strategies.

Methods

We used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity.

Results

In addition to macrophages, we found a high proportion of αβ T cells in the coronary plaques. Most of these T cells

SUBMITTER: Chowdhury RR 

PROVIDER: S-EPMC9286288 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature