Platelet proteome reveals features of cell death, antiviral response and viral replication in covid-19.

ABSTRACT: Coronavirus disease 2019 (COVID-19) has affected over 400 million people worldwide, leading to 6 million deaths. Among the complex symptomatology of COVID-19, hypercoagulation and thrombosis have been described to directly contribute to lethality, pointing out platelets as an important SARS-CoV-2 target. In this work, we explored the platelet proteome of COVID-19 patients through a label-free shotgun proteomics approach to identify platelet responses to infection, as well as validation experiments in a larger patient cohort. Exclusively detected proteins (EPs) and differentially expressed proteins (DEPs) were identified in the proteomic dataset and thus classified into biological processes to map pathways correlated with pathogenesis. Significant changes in the expression of proteins relat

SUBMITTER: Trugilho MRO 

PROVIDER: S-EPMC9287722 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature