Dataset Information

Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry.

ABSTRACT:

Aims

To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events.

Methods and results

Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with HCM and SARS-Cov-2 infection were enrolled. The control group consisted of 91 131 infected individuals. Endpoints were (i) SARS-CoV-2 related mortality and (ii) severe clinical course [death or intensive care unit (ICU) admission]. New onset of atrial fibrillation, ventricular arrhythmias, shock, stroke, and cardiac arrest were also recorded. Sixty-nine (22.9%) HCM patients were hospitalized for non-ICU level care, and 21 (7.0%) required ICU care. Seventeen (5.6%) died: eight (2.6%) of respiratory failure, four (1.3%) of heart failure, two (0.7%) suddenly, and three (1.0%) due to other SARS-CoV-2-related complications. Covariates associated with mortality in the multivariable were age {odds ratio (OR) per 10 year increase 2.25 [95% confidence interval (CI): 1.12-4.51], P = 0.0229}, baseline New York Heart Association class [OR per one-unit increase 4.01 (95%CI: 1.75-9.20), P = 0.0011], presence of left ventricular outflow tract obstruction [OR 5.59 (95%CI: 1.16-26.92), P = 0.0317], and left ventricular systolic impairment [OR 7.72 (95%CI: 1.20-49.79), P = 0.0316]. Controlling for age and sex and comparing HCM patients with a community-based SARS-CoV-2 cohort, the presence of HCM was associated with a borderline significant increased risk of mortality OR 1.70 (95%CI: 0.98-2.91, P = 0.0600).

Conclusions

Over one-fourth of HCM patients infected with SARS-Cov-2 required hospitalization, including 6% in an ICU setting. Age and cardiac features related to HCM, including baseline functional class, left ventricular outflow tract obstruction, and systolic impairment, conveyed increased risk of mortality.

SUBMITTER: Gimeno JR

PROVIDER: S-EPMC9288745 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry.

Gimeno Juan R JR Olivotto Iacopo I Rodríguez Ana Isabel AI Ho Carolyn Y CY Fernández Adrián A Quiroga Alejandro A Espinosa Mari Angeles MA Gómez-González Cristina C Robledo María M Tojal-Sierra Lucas L Day Sharlene M SM Owens Anjali A Barriales-Villa Roberto R Larrañaga Jose María JM Rodríguez-Palomares Jose J González-Del-Hoyo Maribel M Piqueras-Flores Jesús J Reza Nosheen N Chumakova Olga O Ashley Euan A EA Parikh Victoria V Wheeler Matthew M Jacoby Daniel D Pereira Alexandre C AC Saberi Sara S Helms Adam S AS Villacorta Eduardo E Gallego-Delgado María M de Castro Daniel D Domínguez Fernando F Ripoll-Vera Tomás T Zorio-Grima Esther E Sánchez-Martínez José Carlos JC García-Álvarez Ana A Arbelo Elena E Mogollón María Victoria MV Fuentes-Cañamero María Eugenia ME Grande Elias E Peña Carlos C Monserrat Lorenzo L Lakdawala Neal K NK

ESC heart failure 20220603 4

<h4>Aims</h4>To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events.<h4>Methods and results</h4>Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with HCM and SARS-Cov-2 infection were enrolled. The control group consisted of 91 131 infected individuals. Endpoints were (i) SARS-CoV-2 related mortality and (ii) severe clinical course [ ...[more]

PMID: 36255281

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Dataset Information

Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry.

Aims

Methods and results

Conclusions

Publications

Impact of SARS-Cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry.

Similar Datasets

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