Unknown

Dataset Information

0

The search for anti-oxytotic/ferroptotic compounds in the plant world.


ABSTRACT: Oxytosis/ferroptosis is a form of non-apoptotic regulated cell death characterized by glutathione (GSH) depletion and dysregulated production of mitochondrial ROS that results in lethal lipid peroxidation. As the significance of oxytosis/ferroptosis to age-associated human diseases is now beginning to be appreciated, the development of innovative approaches to identify novel therapeutics that target the oxytosis/ferroptosis pathway could not be more timely. Due to their sessile nature, plants are exposed to a variety of stresses that trigger physiological changes similar to those found in oxytosis/ferroptosis. As such, they have evolved a rich array of chemical strategies to deal with those challenging conditions. This review details a drug discovery approach for identifying potent inhibitors of oxytosis/ferroptosis from plants for the treatment of Alzheimer's disease and related dementias, thereby highlighting the tremendous potential of plant-based research for developing new medicines while simultaneously being a catalyst for sustainability.

SUBMITTER: Soriano-Castell D 

PROVIDER: S-EPMC9291238 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

The search for anti-oxytotic/ferroptotic compounds in the plant world.

Soriano-Castell David D   Liang Zhibin Z   Maher Pamela P   Currais Antonio A  

British journal of pharmacology 20210606 18


Oxytosis/ferroptosis is a form of non-apoptotic regulated cell death characterized by glutathione (GSH) depletion and dysregulated production of mitochondrial ROS that results in lethal lipid peroxidation. As the significance of oxytosis/ferroptosis to age-associated human diseases is now beginning to be appreciated, the development of innovative approaches to identify novel therapeutics that target the oxytosis/ferroptosis pathway could not be more timely. Due to their sessile nature, plants ar  ...[more]

Similar Datasets

| S-EPMC8639737 | biostudies-literature
| S-EPMC8199290 | biostudies-literature
| S-EPMC8804037 | biostudies-literature
| S-EPMC11219506 | biostudies-literature
| 2002901 | ecrin-mdr-crc
| S-EPMC7946422 | biostudies-literature
| S-EPMC6835566 | biostudies-literature
| S-EPMC9494174 | biostudies-literature
| S-EPMC7176603 | biostudies-literature
| S-EPMC6496896 | biostudies-literature