Ontology highlight
ABSTRACT:
SUBMITTER: Soriano-Castell D
PROVIDER: S-EPMC9291238 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Soriano-Castell David D Liang Zhibin Z Maher Pamela P Currais Antonio A
British journal of pharmacology 20210606 18
Oxytosis/ferroptosis is a form of non-apoptotic regulated cell death characterized by glutathione (GSH) depletion and dysregulated production of mitochondrial ROS that results in lethal lipid peroxidation. As the significance of oxytosis/ferroptosis to age-associated human diseases is now beginning to be appreciated, the development of innovative approaches to identify novel therapeutics that target the oxytosis/ferroptosis pathway could not be more timely. Due to their sessile nature, plants ar ...[more]