Recombination events drives the emergence of Colombian Helicobacter pylori subpopulations with self-identity ancestry.

ABSTRACT: Helicobacter pylori have coevolved with mankind since its origins, adapting to different human groups. In America, H. pylori has evolved into several subpopulations. We analysed the genome of 154 Colombian strains along with 1,091 strains from worldwide populations to discern the ancestry and adaption to Colombian people. Population structure and ancestry was inferred with FineStructure and ChromoPainter. Phylogenetic relationship and the relative effect of recombination were analysing the core SNPs. Also, a Fst index was calculated to identify the gene variants with the strongest fixation in the Colombian subpopulations compared to their parent population hspSWEurope. FineStructure allowed the identification of two Colombian subpopulations, the previously described

SUBMITTER: Guevara-Tique AA 

PROVIDER: S-EPMC9291697 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature