Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy.

ABSTRACT:

Purpose

The prevalence of food allergy, triggered by T-helper type 2 (Th2) cell-mediated inflammation, is increasing worldwide. Interleukin (IL)-18 plays an important role in inflammatory diseases by binding with the IL-18 receptor. IL-18/IL-18 receptor α (IL-18Rα) is a cofactor for immunoglobulin E (IgE) production and Th2 cell development. Studies have not investigated the association between the IL-18/IL-18Rα signaling pathway and food allergy. Here, we investigated the role of IL-18Rα in food allergy induction and development.

Methods

Wild-type (WT) and IL-18Rα-null mutant (IL-18Rα^-/-) C57BL/6 mice were sensitized and challenged using ovalbumin (OVA) for food allergy induction. Food allergy symptoms, T cell-mediated immune responses, and signal transducer and

SUBMITTER: Kim EG 

PROVIDER: S-EPMC9293601 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature