Severe food allergy reactions are associated with α-tryptase.

ABSTRACT:

Background

Increased TPSAB1 copy numbers encoding ⍺-tryptase are associated with severe reactions in adults with Hymenoptera venom allergy, systemic mastocytosis, and idiopathic anaphylaxis.

Objective

The primary objective was to assess the association between ⍺-tryptase and severity of food allergy.

Methods

A total of 119 subjects underwent tryptase genotyping; 82 of them were from an observational food allergy cohort at the National Institute of Allergy and Infectious Disease (NIAID), and 37 were from a cohort of children who reacted to peanut oral food challenge (OFC) at Lurie Children's Hospital of Chicago. The primary predictor was presence or absence of ⍺-tryptase. The primary outcomes for both cohorts were measures of severity of food allergy reaction. Secondar

SUBMITTER: Lang A 

PROVIDER: S-EPMC10592152 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature