Structural basis for the activation and ligand recognition of the human oxytocin receptor.

ABSTRACT: The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central role in the regulation of social behaviour and sexual reproduction. Here we report the single-particle cryo-electron microscopy structure of the active oxytocin receptor (OTR) in complex with its cognate ligand oxytocin. Our structure provides high-resolution insights into the OT binding mode, the OTR activation mechanism as well as the subtype specificity within the oxytocin/vasopressin receptor family.

SUBMITTER: Waltenspuhl Y 

PROVIDER: S-EPMC9293896 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature