Interplay of Polarity and Confinement in Asymmetric Catalysis with Chiral Rh Diene Complexes in Microemulsions.

ABSTRACT: Microemulsions provide a unique opportunity to tailor the polarity and liquid confinement in asymmetric catalysis via nanoscale polar and nonpolar domains separated by a surfactant film. For chiral diene Rh complexes, the influence of counterion and surfactant film on the catalytic activity and enantioselectivity remained elusive. To explore this issue chiral norbornadiene Rh(X) complexes (X=OTf, OTs, OAc, PO₂ F₂ ) were synthesized and characterized by X-ray crystallography and theoretical calculations. These complexes were used in Rh-catalyzed 1,2-additions of phenylboroxine to N-tosylimine in microemulsions stabilized either exclusively by n-octyl-β-D-glucopyranoside (C₈ G₁ ) or a C₈ G₁ -film doped with anionic or cationic

SUBMITTER: Kirchhof M 

PROVIDER: S-EPMC9299057 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature