Dataset Information

Self-reported exercise-induced dyspnea and airways obstruction assessed by oscillometry and spirometry in adolescents.

ABSTRACT:

Background

Self-reported exercise-induced dyspnea (EID) is common among adolescents. Possible underlying pathologies are exercise-induced bronchoconstriction (EIB) and laryngeal obstruction (EILO). The forced oscillation technique (FOT) may evaluate exercise-induced changes in airway caliber.

Aim

To investigate in adolescents the relationship between EID, EIB (post-exercise fall in forced expiratory volume in 1s (FEV₁ )≥10%), EILO, and post-exercise challenge changes in FOT parameters.

Methods

One hundred and forty-three subjects (97 with EID) of 13-15 years old underwent a standardized exercise challenge with FOT measurement and spirometry repeatedly performed between 2 and 30 min post-exercise. EILO was studied in a subset of 123 adolescents. Subjects showing greater changes than the healthy subgroup in the modulus of the inspiratory impedance were considered FOT responders.

Results

EID-nonEIB subjects presented similar post-exercise changes in all FOT parameters to nonEID-nonEIB adolescents. Changes in all FOT parameters correlated with FEV₁ fall. 45 of 97 EID subjects responded neither by FEV₁ nor FOT to exercise. 19 and 18 subjects responded only by FEV₁ (onlyFEV₁ responders) or FOT (onlyFOTresponders), respectively. Only a lower baseline forced vital capacity (FVC)%predicted and a higher FEV₁ /FVC distinguished the onlyFEV₁ responders from onlyFOTresponders. FOT parameters did not present specific post-exercise patterns in EILO subjects.

Conclusion

FOT can be used to identify post-exercise changes in lower airway function. However, EID has a modest relation with both FEV₁ and FOT responses, highlighting the need for objective testing. More research is needed to understand whether onlyFEV₁ responders and onlyFOTresponders represent different endotypes.

SUBMITTER: Veneroni C

PROVIDER: S-EPMC9299675 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Publications

Self-reported exercise-induced dyspnea and airways obstruction assessed by oscillometry and spirometry in adolescents.

Veneroni Chiara C Pompilio Pasquale Pio PP Alving Kjell K Janson Christer C Nordang Leif L Dellacà Raffaele R Johansson Henrik H Malinovschi Andrei A

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20211209 1

<h4>Background</h4>Self-reported exercise-induced dyspnea (EID) is common among adolescents. Possible underlying pathologies are exercise-induced bronchoconstriction (EIB) and laryngeal obstruction (EILO). The forced oscillation technique (FOT) may evaluate exercise-induced changes in airway caliber.<h4>Aim</h4>To investigate in adolescents the relationship between EID, EIB (post-exercise fall in forced expiratory volume in 1s (FEV<sub>1</sub> )≥10%), EILO, and post-exercise challenge changes in ...[more]

PMID: 34797002

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Project description:Understanding the sources of the large individual differences in sedentary behavior is of great importance as this behavior is associated with pre-mature mortality and non-communicable diseases. Here, we report on the contribution of genetic and environmental factors to the variation in objectively assessed (accelerometer) sedentary behavior and self-reported sitting and their shared genetic basis. In addition, the overlap of the genetic risk factors influencing sedentary time and moderate-to-vigorous physical activity (MVPA) was estimated. A sample of 800 individuals (twins and their siblings) was equipped with an Actigraph accelerometer for 7 days and reported on their sitting time and time spent on MVPA on those days using the IPAQ-SF. Genetic factors explained 56% (CI: 44%, 65%) of the individual differences in objective sedentary behavior (Actigraph) and 26% (CI: 0%, 51%) of the individual differences in self-reported sedentary behavior (IPAQ-SF). A modest correlation (0.33) was found between these measures, which was for 45% accounted for by genetic influences. The genetic correlation was 0.49 reflecting a partly overlapping set of genes that influenced both measurements. A modest correlation (-0.27) between Actigraph-derived sedentary time and MVPA was found, which was 13% accounted for by genetic effects. The genetic correlation was -0.31, indicating that there are overlapping genetic variants that increase sedentary time and decrease MVPA or vice versa. To conclude, more than half of the individual differences in objective sedentary time could be attributed to genetic differences, while for self-reported sitting this was much lower. In addition, using objective measurements, this study confirms that sedentary time is not simply the inverse of MVPA. Future studies are needed to understand the pathways translating genomic variation into variation in these behaviors and how this knowledge might feed into the development of health promotion interventions.

Dataset Information

Self-reported exercise-induced dyspnea and airways obstruction assessed by oscillometry and spirometry in adolescents.

Background

Aim

Methods

Results

Conclusion

Publications

Self-reported exercise-induced dyspnea and airways obstruction assessed by oscillometry and spirometry in adolescents.

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