Dataset Information

Acquired platelet storage container leaks and contamination with environmental bacteria: A preventable cause of bacterial sepsis.

ABSTRACT:

Background

Apheresis platelets (AP) may be contaminated by environmental bacteria via container defects acquired during processing, transport, storage, or transfusion, as highlighted by a recent series of septic reactions related to Acinetobacter spp. and other bacterial strains.

Study design and methods

The frequency and nature of acquired container defect reports to one manufacturer were evaluated from January 2019 to July 2020. The published incidence of contamination and sepsis due to environmental bacteria with culture screened AP in the United States was reviewed for the period of 2010-2019.

Results

Review of a manufacturers' records showed 23 US reports of leaks involving 24 containers attributed to postmanufacturing damage, at a rate of 44 per million distributed storage containers. Analysis of returned containers showed evidence of scratches, impressions, and/or piercings. Literature review of US hemovigilance data revealed that environmental bacteria comprised 7% of confirmed positive primary bacterial culture screens, were responsible for 14%-16% of reported septic, and 8 of 28 (29%) fatal reactions with bacterial-culture screened AP. Sepsis cases have been reported with culture screened, point-of-issue (POI) tested, or pathogen-reduced AP.

Discussion

Environmental contamination of AP is rare but can cause sepsis. Container damage provides a pathway for contamination after culture screening, POI bacteria testing, or pathogen reduction. Blood collectors and transfusion services should have procedures to ensure proper inspection, handling, storage, and transport of AP to avoid damage and should enhance efforts to detect defects prior to release and to eliminate bacteria from all contacting surfaces to minimize the risk of contamination.

SUBMITTER: Gammon RR

PROVIDER: S-EPMC9299677 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

Acquired platelet storage container leaks and contamination with environmental bacteria: A preventable cause of bacterial sepsis.

Gammon Richard R RR Reik Rita A RA Stern Marc M Vassallo Ralph R RR Waxman Dan A DA Young Pampee P PP Benjamin Richard J RJ

Transfusion 20211220 3

<h4>Background</h4>Apheresis platelets (AP) may be contaminated by environmental bacteria via container defects acquired during processing, transport, storage, or transfusion, as highlighted by a recent series of septic reactions related to Acinetobacter spp. and other bacterial strains.<h4>Study design and methods</h4>The frequency and nature of acquired container defect reports to one manufacturer were evaluated from January 2019 to July 2020. The published incidence of contamination and sepsi ...[more]

PMID: 34927291

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Dataset Information

Acquired platelet storage container leaks and contamination with environmental bacteria: A preventable cause of bacterial sepsis.

Background

Study design and methods

Results

Discussion

Publications

Acquired platelet storage container leaks and contamination with environmental bacteria: A preventable cause of bacterial sepsis.

Similar Datasets

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