Acquired platelet storage container leaks and contamination with environmental bacteria: A preventable cause of bacterial sepsis.

ABSTRACT:

Background

Apheresis platelets (AP) may be contaminated by environmental bacteria via container defects acquired during processing, transport, storage, or transfusion, as highlighted by a recent series of septic reactions related to Acinetobacter spp. and other bacterial strains.

Study design and methods

The frequency and nature of acquired container defect reports to one manufacturer were evaluated from January 2019 to July 2020. The published incidence of contamination and sepsis due to environmental bacteria with culture screened AP in the United States was reviewed for the period of 2010-2019.

Results

Review of a manufacturers' records showed 23 US reports of leaks involving 24 containers attributed to postmanufacturing damage, at a rate of 44 per million distribu

SUBMITTER: Gammon RR 

PROVIDER: S-EPMC9299677 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature