Unknown

Dataset Information

0

Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3.

ABSTRACT: Two new pyranone derivatives phomapyrone A (2) and phomapyrone B (3), one new coumarin 11S, 13R-(+)-phomacumarin A (1), three known pyranones (4-6), together with three known amide alkaloids fuscoatramides A-C (7-9), as well as 9S, 11R-(+)-ascosalitoxin (10) were isolated from the endophytic fungus Phoma sp. YN02-P-3, which was isolated from the healthy leaf tissue of a Paulownia tree in Yunnan Province, China. Their structures were elucidated using extensive NMR spectroscopic and HRESIMS data and by comparing the information with literature data. In addition, all compounds were tested for their cytotoxicity activity against human tumor cell lines, and the results showed that new compounds 1-3 showed moderate inhibitory activity against the HL-60 cell line with IC50 values of 31.02, 34.62, and 27.90 μM, respectively.

SUBMITTER: Yu C 

PROVIDER: S-EPMC9300907 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus <i>Phoma</i> sp. YN02-P-3.

Yu Chong C   Nian Yin Y   Chen Huanhua H   Liang Shuwen S   Sun Mengyang M   Pei Yuehu Y   Wang Haifeng H  

Frontiers in chemistry 20220707

Two new pyranone derivatives phomapyrone A (2) and phomapyrone B (3), one new coumarin 11<i>S,</i> 13<i>R</i>-(+)-phomacumarin A (1), three known pyranones (4-6), together with three known amide alkaloids fuscoatramides A-C (7-9), as well as 9<i>S,</i> 11<i>R</i>-(+)-ascosalitoxin (10) were isolated from the endophytic fungus <i>Phoma</i> sp. YN02-P-3, which was isolated from the healthy leaf tissue of a Paulownia tree in Yunnan Province, China. Their structures were elucidated using extensive N  ...[more]

Similar Datasets

Unknown New Pyranone Derivatives and Sesquiterpenoid Isolated from the Endophytic Fungus <i>Xylaria</i> sp. Z184.
| S-EPMC11051921 | biostudies-literature
Unknown Phomapyrrolidones A-C, antitubercular alkaloids from the endophytic fungus Phoma sp. NRRL 46751.
| S-EPMC3896239 | biostudies-literature
Unknown New chlamydosporol derivatives from the endophytic fungus Pleosporales sp. Sigrf05 and their cytotoxic and antimicrobial activities.
| S-EPMC7234987 | biostudies-literature
Unknown Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1).
| S-EPMC5484096 | biostudies-literature
Unknown Three new resveratrol derivatives from the mangrove endophytic fungus Alternaria sp.
| S-EPMC4052320 | biostudies-literature
Unknown Draft genome sequence of the endophytic fungus <i>Phoma</i> sp. strain YAFEF320, isolated from <i>Gerbera jamesonii</i>.
| S-EPMC10793338 | biostudies-literature
Unknown Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY₂.
| S-EPMC5192454 | biostudies-literature
Unknown New Furan Derivatives from a Mangrove-Derived Endophytic Fungus Coriolopsis sp. J5.
| S-EPMC6155590 | biostudies-literature
Unknown Anti-proliferative ambuic acid derivatives from Hawaiian endophytic fungus Pestalotiopsis sp. FT172.
| S-EPMC5542815 | biostudies-literature
Unknown Pentacyclic Cytochalasins and Their Derivatives from the Endophytic Fungus Phomopsis sp. xz-18.
| S-EPMC8587572 | biostudies-literature