Associations of the A118G OPRM1 polymorphism with sociotropy and interpersonal sensitivity.

ABSTRACT:

Background

The μ-opioid receptor (MOR) plays an important role in social bonding behaviors, while it is implicated in the pathophysiology of depression. It is shown that the A118G polymorphism (rs1799971) of the MOR gene (OPRM1) causes amino-acid exchange from Asn to Asp, and that this polymorphism is associated with altered mu-opioid receptor function. Meanwhile, sociotropy/autonomy and interpersonal sensitivity are personality vulnerabilities to depression characterized by distinctive interpersonal styles. The present study tested the hypothesis that the functional A118G OPRM1 polymorphism influences these personality traits.

Methods

The subjects were 402 physically and mentally healthy Japanese volunteers. Sociotropy and autonomy were measured by the Sociotropy-Autonomy S

SUBMITTER: Suzuki A 

PROVIDER: S-EPMC9304853 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature