Adipose-derived stem cells attenuate acne-related inflammation via suppression of NLRP3 inflammasome.

ABSTRACT:

Background

Acne is a chronic facial disease caused by Propionibacterium acnes, which proliferates within sebum-blocked skin follicles and increases inflammatory cytokine production. Several therapeutic drugs and products have been proposed to treat acne, yet no single treatment that ensures long-term treatment efficacy for all patients is available. Here, we explored the use of facial autologous fat transplant of adipose-derived stem cells (ADSCs) to dramatically reduce acne lesions.

Methods

THP-1 cells were treated with active P. acnes for 24 h at different multiplicities of infection, and alterations in inflammatory factors were detected. To study the effect of THP-1 on inflammasome-related proteins, we first co-cultured ADSCs with THP-1 cells treated with P. acnes and eva

SUBMITTER: Li X 

PROVIDER: S-EPMC9308350 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature