Microcalcification and Thoracic Aortopathy: A Window Into Disease Severity.

ABSTRACT:

Background

Patients with thoracic aortopathy are at increased risk of catastrophic aortic dissection, carrying with it substantial mortality and morbidity. Although granular medial calcinosis (medial microcalcification) has been associated with thoracic aortopathy, its relationship to disease severity has yet to be established.

Methods

One hundred one thoracic aortic specimens were collected from 57 patients with thoracic aortopathy and 18 control subjects. Standardized histopathologic scores, immunohistochemistry, and nanoindentation (tissue elastic modulus) were compared with the extent of microcalcification on von Kossa histology and 18F-sodium fluoride autoradiography.

Results

Microcalcification content was higher in thoracic aortopathy samples with mild (n=28; 6.

SUBMITTER: Fletcher AJ 

PROVIDER: S-EPMC9311465 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature