Ontology highlight
ABSTRACT:
SUBMITTER: Wojtczak K
PROVIDER: S-EPMC9321714 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Wojtczak Karolina K Byrne Joseph P JP
ChemMedChem 20220503 12
Pseudomonas aeruginosa is a pathogenic bacterium, responsible for a large portion of nosocomial infections globally and designated as critical priority by the World Health Organisation. Its characteristic carbohydrate-binding proteins LecA and LecB, which play a role in biofilm-formation and lung-infection, can be targeted by glycoconjugates. Here we review the wide range of inhibitors for these proteins (136 references), highlighting structural features and which impact binding affinity and/or ...[more]