Light Triggers the Antiproliferative Activity of Naphthalimide-Conjugated (η⁶-arene)ruthenium(II) Complexes.

ABSTRACT: We report the synthesis and characterization of three half-sandwich Ru(II) arene complexes [(η⁶-arene)Ru(N,N')L][PF₆]₂ containing arene = p-cymene, N,N' = bipyridine, and L = pyridine meta- with methylenenaphthalimide (C1), methylene(nitro)naphthalimide (C2), or methylene(piperidinyl)naphthalimide (C3). The naphthalimide acts as an antenna for photoactivation. After 3 h of irradiation with blue light, the monodentate pyridyl ligand had almost completely dissociated from complex C3, which contains an electron donor on the naphthalimide ring, whereas only 50% dissociation was observed for C1 and C2. This correlates with the lower wavelength and strong absorption of C3 in this region of the spectrum (λ_max = 418 nm) compared with C1 and C2 (λ_max

SUBMITTER: Bisceglie F 

PROVIDER: S-EPMC9322830 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature