Anti-Inflammatory Activity of Piquerol Isolated from Piqueria trinervia Cav.

ABSTRACT:

Background

Inflammation is a complex process as a response to several stimuli, such as infection, a chemical irritant, and the attack of a foreign body. Piquerol was isolated from Piqueria trinervia, and its anti-inflammatory activity was evaluated using in vivo and in vitro models.

Methods

Piquerol is a monoterpene that was identified using NMR, FT-IR spectroscopy, and mass spectrometry analysis. The anti-inflammatory activity was tested in vivo in ear edema induced with TPA in mice. Piquerol was also tested on J774A.1 macrophages stimulated with lipopolysaccharide (LPS), and the levels of NO, NF-κB, TNF-α, IL-1β, IL-6, and IL-10 were determined using ELISA.

Results

The results show that piquerol diminished ear edema (66.19%). At 150.51 µM, it also inhibited t

SUBMITTER: Campos-Xolalpa N 

PROVIDER: S-EPMC9324079 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature